nginx logs error that cause connection refuse

I have cent os 7 server that working with apache, nginx and perl but it has many errors while connecting to files on the server In my nginx log i found the following errors * send() failed (111: Connection refused) * send() to syslog failed while logging request * perl: speed: 1048576 (11: Resource temporarily unavailable) * client timed out (110: Connection timed out) while waiting for request * client prematurely closed connection (104: Connection reset by peer) while sending response to client # if you don't have experience please don't bid # work only using teamviewer or anydesk