8952 Need Windows Server Expert

I have a program that I can't get to work on my windows server. It is a regular exe and it should open. I've tried everything, from changing versions of windows, etc but it won't open. The weird thing is it opens fine on my home Windows XP and some other windows 2003 and windows 2000 in the past. Need someone to help me work out why it won't open and get it to open. thanks